The Prisoner, an amorphous creature capable of possessing dead bodies, awakens in the depths of an island prison with no memory. A soldier tells the Prisoner they can no longer die. Through repeated escape attempts, the Prisoner learns that the island was once a powerful kingdom brought to ruin when a plague called "The Malaise" transformed most of its citizens into mutated monsters. After escaping the prison depths, the Prisoner resolves to kill the island's reclusive King, believing that his death will change something on the island. Fighting through plague-infested regions, the Prisoner reaches the throne room and slays the comatose monarch, only for the King's corpse to explode violently, destroying the Prisoner's host body. The head crawls through a fountain drain that leads back to the prison, where the cycle begins again.