Several years after his last adventure, Nathan Drake has retired from fortune hunting and settled into a quiet life with his wife Elena. When his long-lost brother Sam, presumed dead for fifteen years, reappears claiming he needs help finding the treasure of pirate Henry Avery to pay off a dangerous debt, Nate is pulled back into his old life. Aided by longtime partner Sully, the Drake brothers follow a trail of clues from Italy to Madagascar and Scotland, pursued by wealthy rival treasure hunter Rafe Adler and his private military force. The search leads them toward Libertalia, a legendary pirate colony, where Nate must confront the cost of obsession and decide what he is willing to sacrifice for one last score.